ОңТҮстік қазақстан медицина академиясы, хабаршы №4 942, 2021 жыл, том 2


К Л И Н И Ч Е С К А Я М Е Д И Ц И Н А



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К Л И Н И Ч Е С К А Я М Е Д И Ц И Н А 
 
Қауызбай Ж.Ә., Сейдахметова А.А., Оспанбек А.К., Ходжакулова У.А., Мусаева А.Г.
 
СОПУТСТВУЮЩИЕ ЗАБОЛЕВАНИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ У 
ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЕГКИХ 
126 
Таштемиров С.Ф.
ОПЫТ ПРИМЕНЕНИЯ ПРЕПАРАТА «АНДРОГЕЛЬ» У МУЖЧИН С ПРИЗНАКАМИ 
ГИПОГОНАДИЗМА
 
131 
 
ТЕОРЕТИЧЕСКАЯ МЕДИЦИНА 
 
Poshyvak O.B.
RAPAMYCIN ACTION UPON KINDLED SEIZURE ACTIVITY IN RATS 
133 
 
 
 

Document Outline

  • 3. M. Honma, A. Kitazawa, A. Cayley, R. V. Williamset all. Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project. Mutagenesis. 2019 Mar; 34(...
  • 4. Г.Габдуллина Остеопороз и правильное питание/2018г.
    • BIOETHANOL EMISSIONS
      • UDC 60
    • TECHNOLOGY APPLICATIONS FOR BIOETHANOL
      • Spark Ignition Engines
      • Compression Ignition Engines
      • UDC 60
  • BIOHYDROGEN PRODUCTION
    • UDC 60
    • Cellulosic Feedstock.Besides the so called first generation feedstock which is received from sugar and starch crops, cellulosic feedstock is a promising source for bioethanol production in the future. Since the technology for converting cellulosic fee...
    • USE SUGAR CROPS FOR PRODUCTION BIOFUEL
  • Introduction
  • Inhibitors of the mammalian target of rapamycin (mTOR) pathway are recognized as perspective antiepileptic compounds (19,21). Such pharmacons are different from classical antiepileptic drugs and cause a broad spectrum of effects, including modificatio...
  • Such data favors the mTOR inhibitors as a new and promising approach to epilepsy treatment (4, 8, 9, 11, 15, 18). Antiseizure action of rapamycin – well-known mTOR inhibitor has been shown on kainic acid induced continuous seizures (21), epileptic sta...
  • That is why this work's main aim was to investigate the effects of rapamycin upon pentylenetetrazol (PTZ)-induced kindled convulsions. Considering that PTZ-kindled seizures are highly sensitive to valproic acid's antiseizure action [10], the compariso...
  • Materials and Methods
  • Experiments were performed on male Wistar rats with initial bodyweight 200-250 g. Animals were kept in standard conditions (constant temperature 23o C and relative humidity 60%, 12 hrs dark/light cycles, standard diet, and tap water were given ad libi...
  • Kindled convulsions were induced, as described previously [6]. PTZ ("Sigma Aldrich") was given intraperitoneally (i.p.) daily in a dose of 30.0 mg/kg for 21 days. The severity of convulsions was evaluated according to the following criteria:
  • Results
  • Behavioral characteristics of the convulsions in kindled rats
  • Repeated i.p. administration of PTZ (35.0 mg/kg) resulted in the progressive development of seizure manifestations, starting from the third to sixth injection. At the moment of completion of kindling – after the 21-t PTZ administration, a prevalent nu...
  • Effects of rapamycin and valproic acid
  • Administration of rapamycin in doses of 0.3; 1.0 and 3.0 mg/kg, i.p. resulted in a dose-dependent decrease in the severity of kindled convulsions. Statistical significance was achieved at a dosage of 1.0 mg/kg (Table 1), at which dose 6 of 9 animals w...
  • Administration of valproic acid to kindled animals (50.0; 100.0 and 250.0 mg/kg, i.p.) resulted in a dose-dependent seizure-protecting effect that was statistically significant for two doses, 100.0 and 250.0 mg/kg (Table 1) as compared with controls (...
  • Table 1
  • Statistics performed by Kruscall-Wallis and Mann-Whitney U tests.
  • References
  • 1. Bender D.K., Routbort M.J., Ryan T.E. et al. Selective inhibition of kindling development by intraventricular administration of TrkB receptor antibody. J. Neurosci. 1999; 19: 1424–1436.
  • 2. Benini R., Roth R., Khoja Z. et al. Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy ? Int. J. Devl. Neuroscience. 2016; 49: 31-36.
  • 3. Bhargava P., Robinson M.O. Development of second-generation VEGFR tyrosine kinase inhibitors: Current status. Curr. Oncol. Rep. 2011; 13: 103–111.
  • 4. Buckmaster P.S., Ingram E.A., Wen X. Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci. 2009; 29: 8259–8269.
  • 5. Cho C.H. Frontier of epilepsy research - mTOR signaling pathway. Exp. Mol. Med. 2011; 43: 231–274.
  • 6. Chubach V.S., Muratova T.N., Myronenko S.I., Godlevsky L.S. Antiepileptic effects of axitinib on pentylenetetrazol- induced kindling in rats. Epilepsia. 2015; 56 (suppl.1): 0142.
  • 7. McDaniel S.S., Wong M. Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis. Neurosci. Lett. 2011; 497: 231–239.
  • 8. Galanopoulou A.S., Gorter J.A., Cepeda C. Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. Epilepsia. 2012; 53: 1119–1130.
  • 9. Gorter J.A., van Vliet E.A., Aronica E., et al. Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J. Neurosci. 2006; 26: 11083–11110.
  • 21. Zeng L.H., Rensing N.R., Wong M. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J. Neurosci. 2009; 29: 6964–6972.
  • Аннотация
  • ABSTRACT
  • RAPAMYCIN ACTION UPON KINDLED SEIZURE ACTIVITY IN RATS


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