К Л И Н И Ч Е С К А Я М Е Д И Ц И Н А Қауызбай Ж.Ә., Сейдахметова А.А., Оспанбек А.К., Ходжакулова У.А., Мусаева А.Г.
СОПУТСТВУЮЩИЕ ЗАБОЛЕВАНИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ У
ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЕГКИХ
126
Таштемиров С.Ф.
ОПЫТ ПРИМЕНЕНИЯ ПРЕПАРАТА «АНДРОГЕЛЬ» У МУЖЧИН С ПРИЗНАКАМИ
ГИПОГОНАДИЗМА
131
ТЕОРЕТИЧЕСКАЯ МЕДИЦИНА Poshyvak O.B.
RAPAMYCIN ACTION UPON KINDLED SEIZURE ACTIVITY IN RATS
133
Document Outline
3. M. Honma, A. Kitazawa, A. Cayley, R. V. Williamset all. Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project. Mutagenesis. 2019 Mar; 34(...
4. Г.Габдуллина Остеопороз и правильное питание/2018г.
Cellulosic Feedstock.Besides the so called first generation feedstock which is received from sugar and starch crops, cellulosic feedstock is a promising source for bioethanol production in the future. Since the technology for converting cellulosic fee...
Inhibitors of the mammalian target of rapamycin (mTOR) pathway are recognized as perspective antiepileptic compounds (19,21). Such pharmacons are different from classical antiepileptic drugs and cause a broad spectrum of effects, including modificatio...
Such data favors the mTOR inhibitors as a new and promising approach to epilepsy treatment (4, 8, 9, 11, 15, 18). Antiseizure action of rapamycin – well-known mTOR inhibitor has been shown on kainic acid induced continuous seizures (21), epileptic sta...
That is why this work's main aim was to investigate the effects of rapamycin upon pentylenetetrazol (PTZ)-induced kindled convulsions. Considering that PTZ-kindled seizures are highly sensitive to valproic acid's antiseizure action [10], the compariso...
Experiments were performed on male Wistar rats with initial bodyweight 200-250 g. Animals were kept in standard conditions (constant temperature 23o C and relative humidity 60%, 12 hrs dark/light cycles, standard diet, and tap water were given ad libi...
Kindled convulsions were induced, as described previously [6]. PTZ ("Sigma Aldrich") was given intraperitoneally (i.p.) daily in a dose of 30.0 mg/kg for 21 days. The severity of convulsions was evaluated according to the following criteria:
Results
Behavioral characteristics of the convulsions in kindled rats
Repeated i.p. administration of PTZ (35.0 mg/kg) resulted in the progressive development of seizure manifestations, starting from the third to sixth injection. At the moment of completion of kindling – after the 21-t PTZ administration, a prevalent nu...
Administration of rapamycin in doses of 0.3; 1.0 and 3.0 mg/kg, i.p. resulted in a dose-dependent decrease in the severity of kindled convulsions. Statistical significance was achieved at a dosage of 1.0 mg/kg (Table 1), at which dose 6 of 9 animals w...
Administration of valproic acid to kindled animals (50.0; 100.0 and 250.0 mg/kg, i.p.) resulted in a dose-dependent seizure-protecting effect that was statistically significant for two doses, 100.0 and 250.0 mg/kg (Table 1) as compared with controls (...
Table 1
Statistics performed by Kruscall-Wallis and Mann-Whitney U tests.
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