Ключевые слова : рапамицин, пентиленететразол, хроническая эпилептическая активность,
противоэпилептичские препараты.
ABSTRACT Poshyvak O.B., associate professor, Pharmacology Department, Danylo Halytsky Lviv National Medical
University, Lviv, Ukraine
olesya.poshyvak@gmail.com
RAPAMYCIN ACTION UPON KINDLED SEIZURE ACTIVITY IN RATS The mTOR signal system's activity plays a prominent role in chronic epileptic activity development,
which is modeled via repeated subconvulsive dosage of pentylenetetrazol (PTZ) administration. The
investigation aimed to verify the effects of Rapamycin – blocker of mTOR upon kindled seizures induced
with PTZ in a dosage of 35,0 mg/kg, i.p. Rapamycin was administered in dosages 0,3; 1,0 and 3,0 mg/kg, i.p.
during ten days after fully developed kindled seizures. Sodium valproate (50,0; 100,0 and 250,0 mg/kg, i.p.)
was used as a reference drug. Methocel solution was administered to control kindled animals under identical
conditions. The testing dosage of PTZ (35,0 mg/kg, i.p.) was used on the 11th day from the moment of
treatment beginning, and behavioral seizures scored. It was established that Rapamycin in a dosage of 3,0
mg/kg prevented generalized seizures in all kindled rats, and the pronouncement of seizures was in
correspondence with the effectiveness of valproic acid administered in a dosage of 250,0 mg/kg. The
conclusion of the pronounced antiseizure activity of Rapamycin was made. Such an activity might be
explained by Rapamycin ability to prevent neoangiogenesis, which is very important for kindling- induced
chronic epileptic activity establishment.
Key words : Rapamycin, pentylenetetrazol, chronic epileptic activity, antiepileptic drugs
.
