«Профилактика несостоятельности желудочно-кишечных анастомозов в экстренной хирургии»



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Байланысты:
2.-Аннотация-Джумабеков-Б.Н.

Objectives 
1.
To study the effectiveness of various methods of using platelet-rich auto- 
plasma in the area of the inter-intestinal anastomosis experimentally. 
2.
To prove the mechanical strength, as well as to study the course of the 
regenerative process of the formed anastomoses by injection of platelet-rich auto- 
plasma in the experiment. 
3.
To develop a method for preventing the failure of gastrointestinal 
anastomoses using platelet-rich auto-plasma. 
4.
To assess the effect of the usage of platelet-rich auto-plasma on the 
healing process of the gastrointestinal anastomosis and the course of the early 
postoperative period in emergency surgery. 
5.
Carry out a comparative assessment of the results of treatment in groups 
of patients with the use of platelet-rich auto-plasma in the area of the 
gastrointestinal anastomosis and without it. 
Scientific novelty of study 
1.
For the first time, a method has been developed and applied in the 
experiment to prevent anastomotic leak of intestinal anastomoses by using platelet- 
rich auto-plasma (No. 2018/0657.1, dated September 24, 2018). 
2.
Qualitatively new data on the dynamics of morphological and functional 
changes in the formed anastomosis at different periods of the experiment were 
obtained and the threshold levels of intestinal anastomosis failure were determined. 
3.
For the first time in an experimental study, the mechanical strength of the 
formed intestinal anastomoses was proved by using the proposed method of using 
platelet-rich auto-plasma. 
4.
New data on the effect of platelet-rich auto-plasma on the process of 
adhesion formation under experimental conditions are proven. 
5.
A method has been developed to improve the regeneration of 
gastrointestinal anastomoses by using platelet-enriched auto-plasma (RK Patent 
No. 2019/0691.1, dated 03/19/2021). 
6.
A method has been developed to prevent gastrointestinal anastomotic 
leaks by using an injection method for introducing platelet-rich auto-plasma in 
emergency surgery (Eurasian patent (No. 2019/068, dated 18.09.2019). 
7.
The nature of the course of the postoperative period with the use of 
platelet-rich auto-plasma during the imposition of gastrointestinal anastomoses in 
emergency surgery is shown. 


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