Внутривузовская студенческая
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- Purpose: Perform a comparative evaluation of antioxidant status and examine the potential use of antioxidant system enzymes to correct the infringements. Discussion
| Amangeldiev
N . Scientific supervisor: Olzhayeva R.R., k.b.s., professor of Russian Academy of Natural Sciences Semey Medical University, NCJSC Actuality: In recent years, antioxidants - both natural and synthetic - have been increasingly included in clinical practice, and they work in various fields of medicine - from surgery to psychiatry due to their ability to attain a balance between the production and utilization of reactive oxygen species, and a homeostasis as a whole. Purpose: Perform a comparative evaluation of antioxidant status and examine the potential use of antioxidant system enzymes to correct the infringements. Discussion: In the body, the toxic effect of reactive oxygen species is prevented by the functioning of antioxidant defense systems. Normally, a balance is maintained between oxidative and antioxidant systems. The antioxidant defense system is represented by enzymatic and non - enzymatic components. The increase in the activity of antioxidant system enzymes is obviously associated with the activation of compensatory mechanisms aimed at reducing the level of oxidative stress caused by the action of adverse environmental factors. It is known that excessive accumulation in cells of a superoxide anion - radical or hydrogen peroxide is accompanied by derepression of genome regions responsible for the activity of antiradical cell defense enzymes – superoxidedismutase and catalase. In turn, activation of serum superoxidedismutase prevents the development of cytopathogenic effects of reactive oxygen - destabilization of endotheliocyte and blood cell membranes leading to the development of endothelial dysfunction and atherosclerosis. However, this compensation mechanism is depleted after 72 hours from the development of acute ischemia. So, pharmacological supplementation to this pathological point may be applied. The high intensity of the processes, namely lipid metabolism, 54 occurring in the liver causes its high sensitivity to a lack of oxygen. An activation of lipid peroxidation in the liver plays an important role in metabolic disorders in acute hypoxia. Futhermore, the relationship between the indicators of fetal hemoglobin and oxygen saturation in patients with hemoglobinopathies including sickle cell anemia helps in the early diagnosis of latent chronic hypoxia and hypoxemia, allowing to clarify the severity of the disease and correct treatment. Finally, the antioxidant activity of flavonoids is manifested in an increase in the antioxidant status of plasma including a protective effect of vitamin E. Its action is directed on erythrocyte membranes and low density lipoproteins, as well as the protection of PUFA membranes of red blood cells from peroxidation. жүктеу/скачать 1,56 Mb. Достарыңызбен бөлісу:
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