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muscle mass decreases.As men grow older, androgen secretion decreases, age and mental and metabolic
changes are associated with age - signs of developing android symptoms.
As men grow older, the number of Sertoli cells declines by about 2 times, so their true hematopoiesal
disorders are disturbed, and the number of spermatozoa is gradually decreasing.At the same time
spermatozoa and oocyte fertilization can cause the expression of membrane proteins required for different
layers of oleum and pellucid zones.
In 2003, a survey of healthy men aged 22-80 revealed a decrease in
sperm count and spermatozoa activity on the contrary. In 2008, an article on donating oocytes was published
in men's age study. In the present study, using the oocytes of young and healthy donors, it has been possible
to check the effects of men on the area of embryos and the frequency of childbirth. Most men who took part
in the study were between the ages of 30-60.
According to the results of the study, it was found out that the size of sperm, the concentration and
activity of the sperm begin to decline in men from 45 years, as well as deterioration of spermatozoa
morphology from this age. Teratzoospermia suggests that the likelihood of aneuploidy (40%) among
spermatozoa increases and chromosomal anomalies in 50% of embryos. In 2001, Poulson concluded that
fertilization and fetal frequency decreases in donor oocytes, regardless of the reduction of spermatozoids
concentration. However, in other studies, men have shown that the donor oocytes have a direct effect on the
successful completion of the programs. As a result of the research, the probability of pregnancy has
decreased as the sperm morphology worsens. Earlier, compared with younger age (25-29 years), it was
reported that women in their 40s were at high risk of abortion, and 30-year-old fathers were reported to have
a three-fold higher risk of abortion compared to 25-year-old men.
According to the American Association for Reproductology, men are gaining weight as the age
increases (fatty pressures), and these facts have a negative impact on their reproductive health. As the body
weight index increases, the concentration of spermatozoa in the sperm fluid decreases. Age-related advances
such as DNA damage and degradation have led to anomalies such as Achondroplasia, Schizophrenia,
Autism, Kleinfelter and Apert syndrome among newborn babies. For issues related to this age, the American
Association for Reproductology decides that men who can be donor donors should not exceed 40 years.
Research advisors:
Candidate of Biological Sciences, Associate Professor, Ablaikhanova N.T.,
doctor of biological sciences professor Murzakhmetova M.К., PhD, Professor, Isachenko V.
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