ОңТҮстік қазақстан медицина академиясы, хабаршы №4 942, 2021 жыл, том 2



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Ключевые слова
: рапамицин, пентиленететразол, хроническая эпилептическая активность, 
противоэпилептичские препараты. 
ABSTRACT 
Poshyvak O.B., 
associate professor, Pharmacology Department, Danylo Halytsky Lviv National Medical 
University, Lviv, Ukraine
olesya.poshyvak@gmail.com
 
RAPAMYCIN ACTION UPON KINDLED SEIZURE ACTIVITY IN RATS 
 
The mTOR signal system's activity plays a prominent role in chronic epileptic activity development, 
which is modeled via repeated subconvulsive dosage of pentylenetetrazol (PTZ) administration. The 
investigation aimed to verify the effects of Rapamycin – blocker of mTOR upon kindled seizures induced 
with PTZ in a dosage of 35,0 mg/kg, i.p. Rapamycin was administered in dosages 0,3; 1,0 and 3,0 mg/kg, i.p. 
during ten days after fully developed kindled seizures. Sodium valproate (50,0; 100,0 and 250,0 mg/kg, i.p.) 
was used as a reference drug. Methocel solution was administered to control kindled animals under identical 
conditions. The testing dosage of PTZ (35,0 mg/kg, i.p.) was used on the 11th day from the moment of 
treatment beginning, and behavioral seizures scored. It was established that Rapamycin in a dosage of 3,0 
mg/kg prevented generalized seizures in all kindled rats, and the pronouncement of seizures was in 
correspondence with the effectiveness of valproic acid administered in a dosage of 250,0 mg/kg. The 
conclusion of the pronounced antiseizure activity of Rapamycin was made. Such an activity might be 
explained by Rapamycin ability to prevent neoangiogenesis, which is very important for kindling- induced 
chronic epileptic activity establishment.
Key words
: Rapamycin, pentylenetetrazol, chronic epileptic activity, antiepileptic drugs 

 
 
 
 
 
 


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