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mechanisms of its maintenance (cardiac output, cardiac output, general peripheral resistance), which have
not been adequately studied. The aim of the work was to study the circulatory indices by the method of the
integral regoraphy of the body of animals against the background of intoxication of the organism.
In the experiment, 24 white rats of a heterogeneous population, weighing 180-220 g, were used on a
standard ration of a vivarium with free access to water. The experimental group of animals was
intraperitoneally injected with dinil at a dose of 5 mg / kg of weight and a volume of 0.5 ml / kg for 30 days.
During the last 10 days, parts of the animals from the experimental group were injected intragastrically with
thalerin (a composition consisting of amino acids, vitamins and trace elements). Animals
of the control group
received equivoluminal amounts of saline. Twenty-four hours after the last administration, the animals were
decapitated and blood plasma, liver, heart and brain sections-striatum, middle brain and hypothalamus were
taken for biochemical studies.
In rats with toxic hepatitis, the lymph outflow from the thoracic duct decreased from 0.31 ± 0.02 up to
0,18 ± 0,02 ml / h, on 44% in comparison with parameters of animals
from the control group,
and the content
of total protein in lymph decreased by 30% of the control data. Arterial pressure in the common carotid
artery was 90-100 mm Hg. Art.
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