The practical significance of the work

3.
The method for preventing gastrointestinal anastomotic failure by using 
platelet-rich auto-plasma in emergency surgery is technically simple to perform, 
safe and does not significantly increase the time of surgical intervention. 
4.
Prevention of gastrointestinal anastomotic leak through the use of platelet- 
rich auto-plasma can significantly reduce the incidence of complications. 
Provisions submitted for protection 
1.
The use of injection of platelet-rich auto-plasma in the area of the 
gastrointestinal anastomosis enhances the regenerative process, reduces the level of 
inflammation in the suture area and the severity of the adhesive process, increasing 
the physical and biological tightness of the formed anastomosis. 
2.
The use of platelet-rich auto-plasma in emergency surgery for 
interventions on the gastrointestinal tract with the formation of anastomoses 
significantly reduces the incidence of failure of the formed anastomoses and 
reduces the number of relaparotomies. 
3.
Prevention of gastro-intestinal anastomotic failure by using the "injection" 
method of introducing platelet-rich auto-plasma into the anastomosis area is safe, 
effective and can be used in emergency surgery. 
Conclusions 
1.
The use of the "injection" method of introducing platelet-rich auto-plasma 
into the area of the intestinal anastomosis is effective and safe compared to the 
"impregnation" method in the experiment. 
2.
Injection of platelet-enriched auto-plasma in the area of intestinal 
anastomosis increases their deformation strength parameters (p=0.011), increases 
mucosal epithelialization (p=0.032) and neo-angiogenesis processes (p=0.029), and 
also reduces the severity of adhesions (p=0.011) in comparison with control 
groups. 
3.
Prevention of gastrointestinal anastomotic leak during surgical 
interventions in conditions of emergency surgery is possible by using the 
developed method of "injecting" administration of platelet-rich auto-plasma into 
the area of the gastrointestinal anastomosis. 
4.
The use of platelet-rich auto-plasma in emergency surgery for 
interventions on the gastrointestinal tract in the postoperative period accelerates the 
appearance of peristaltic noises (after 48 hours), reduces the level of leukocytes in 
the blood (p=0.015), and the average body temperature (p<0.05), duration of 
inpatient treatment (from 14.1±2.3 to 10.8±2.1 days), intra-abdominal and extra- 
abdominal complications (p≤0.05). 
5.
Prevention of intestinal anastomotic leaks by using platelet-rich auto- 
plasma in the area of intestinal anastomosis allowed to reduce the number of 
relaparotomies (from 10% to 2%) (p≤0.05), as well as to reduce the overall 
mortality rate (from 6% to 2%) (p≤0.001). 

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