Принято в печать: 30 апреля 2021 г.
Для переписки: Надежда Викторовна Куркина, канд. мед. наук,
ул. Ульянова, д. 26А, Саранск, Российская Федерация, 430032;
тел.: +7(927)172-48-63; e-mail: nadya.kurckina@yandex.ru
Для цитирования: Куркина Н.В., Горшенина Е.И., Чегодаева Л.В.,
Полагимова А.В. Анемия хронических заболеваний.
Клиническая онкогематология. 2021;14(3):347–54.
DOI: 10.21320/2500-2139-2021-14-3-347-354
ANEMIAS
Anemia of Chronic Diseases
NV Kurkina, EI Gorshenina, LV Chegodaeva, AV Polagimova NP Ogarev National Research Mordovia State University,
68 Bolshevistskaya str., Saransk, Russian Federation, 430005
A B ST R AC T Anemia of chronic diseases (ACD) refers to a group of anemi-
as arising in various infl ammatory infections, autoimmune or
tumor diseases due to acute or chronic immune activation.
ACD ranks second in incidence after iron defi ciency anemia
(IDA). Within the variety of pathogenetic mechanisms one of
the primary ones is hepcidin synthesis in hepatocytes, which
blocks iron absorption in the intestine and contributes to its
deposition in cells of the monocyte-macrophage system.
Besides, excessive cytokines in such diseases and patholo-
gies lead to lower eryth ropoietin production which does not
correspond to the severity grade of anemia. This results in
impaired erythropoiesis in the bone marrow. The diff erential
diagnosis should also specify iron defi ciency type (the abs o-
lute one in IDA and the functional one in ACD). The eff ective
treatment of the main disease and anemia correction speed
up the improvement of patient’s status, rehabilitation, and
quali ty of life.
Keywords: anemia, chronic diseases, immune sys-
tem, hepcid in, cytokines, erythropoietin, ferritin, se-
rum iron.
Received: January 17, 2021
Accepted: April 30, 2021
For correspondence: Nadezhda Viktorovna Kurkina, MD, PhD,
26А Ul’yanova str., Saransk, Russian Federation, 430032;
Tel.: +7(927)172-48-63; e-mail: nadya.kurckina@yandex.ru
For citation: Kurkina NV, Gorshenina EI, Chegodaeva LV, Polagimova AV.
Anemia of Chronic Diseases. Clinical oncohematology. 2021;14(3):347–54.
(In Russ).
DOI: 10.21320/2500-2139-2021-14-3-347-354
