|
Neuromediators and neuropeptides: the biomarkers for metabolic disturbances in obesityБайланысты: ProblemyEndokrinologii 2018 04 258Neuromediators and neuropeptides: the biomarkers for metabolic disturbances in obesity
© Ivan V. Gmoshinski*, Sergey A. Apryatin, Vladimir A. Shipelin, Dmitriy B. Nikitjuk
Federal Research Centre of Nutrition, Biotechnology and food safety, Moscow, Russia
The role of biogenic amines (serotonin, dopamine) and neuropeptides in regulation of energy homeostasis of the organism and
their role as markers of metabolic disorders in obesity (Ob) in animal experimental models and in clinical observations is re-
viewed. The energy homeostasis of the body is controlled via competition of alternative regulatory mechanisms that are mainly
localized in the hypothalamus (HT). At the level of aminergic regulation, these are the serotonin and dopamine systems; at the
level of the peptidergic system, these are NPY/AgRP and POMC/CART-related peptides. Opioid and cannabinoid receptors and
their endogenous ligands closely linked to peptidergic and aminergic regulatory subsystems of the central nervous system ensure
the connection between the «metabolic» regulation loop responding to a deficit or excess of energy substrates the «hedonistic»
one associated with the body’s perception of pleasure from food consumption. The response of peptidergic and aminergic HT
neurons to food and hormonal signals originating from the outside is based on the interaction between the corresponding ligands
and G-protein-coupled receptors specific to them. Disruption or breakdown of the central mechanisms is considered to be one of
the main pathogenetic factors of obesity and, simultaneously, the reason why reducing diet therapy proves inefficient or unstable.
Partial permeability of the blood—brain barrier for neuropeptides makes them an attractive biomarker in the diagnosis of meta-
bolic abnormalities in obese patients.
Keywords: obesity, hypothalamus, serotonin, dopamine, neuropeptides, biomarkers.
Список основных сокращений
Достарыңызбен бөлісу: |
|
|
